William Smith

• William Smith (1769-1839), geologist
• William Smith (1728-1814), Representative for Maryland from 1789 to 1890
• William Smith (1751-1837), Representative for South Carolina from 1797 to 1798
• William Smith (1762-1840), Senator from South Carolina from 1815 to 1830

• William Smith, Representative for Virginia from 1821 to 1824
• William Smith, (1797-1887), Representative for Virginia from 1841 to 1860

• Samuel William Smith, (1852-1931), Representative for Michigan from 1897 to 1914
• William Alden Smith, (1859-1932), Representative for Michigan from 1895 to 1906 and Senator from 1905 to 1918
• William Alexander Smith, (1825-1897), Premier of British Columbia), known as Amor De Cosmos
• William Alexander Smith, (1828-1888), Representative for North Carolina from 1873 to 1874
• William E. Smith, Governor of Wisconsin from 1878 to 1882
• William Ephraim Smith, (1829-1890), Representative for Georgia from 1875 to 1880
• William French Smith, United States Attorney General from 1981 to 1985
• William H. Smith, Governor of Alabama from 1868 to 1870
• William Jay Smith, (1823-1913), Representative for Tennessee from 1869 to 1870
• William Loughton Smith, (1758-1812), Representative for South Carolina from 1789 to 1798
• William Nathan Harrell Smith, (1812-1889), Representative for North Carolina from 1859 to 1860
• William Orlando Smith, (1859-1932), Representative for Pennsylvania from 1903 to 1906
• William Robert Smith, (1863-1924), Representative for Texas from 1903 to 1916
• William Russel Smith, (1815-1896), Representative for Alabama from 1851 to 1856
• William Stephens Smith, (1755-1816), Representative for New York from 1813 to 1816